Glucorid 2 | 10 Tablets

✔️ Side Effects

Common: Hypoglycemia, dizziness, nausea, vomiting, abdominal pain

Occasional: Diarrhea, temporary visual disturbance, urticaria, hypotension

✔️ Dosage Guideline

• The goal is to use the lowest effective dose that maintains optimal blood sugar control.
• Regular monitoring of blood and urine glucose is essential to determine dosage accuracy and detect therapy failure.

Initial Dose & Titration

Start with 1 mg once daily, taken before breakfast or the first main meal.

If needed, increase gradually every 1–2 weeks based on glucose monitoring:
1 mg → 2 mg → 3 mg → 4 mg → 6 mg daily.

Maintenance Dose

Usual maintenance dose: 1–4 mg daily, depending on glycemic response.

Patients with improved insulin sensitivity may require dose reduction during long-term treatment.

Changeover from Other Oral Antidiabetics

Begin with 1 mg daily even when switching from maximum doses of other agents.

Consider discontinuing the previous drug temporarily to prevent additive hypoglycemic effects.

Administration

Swallow tablets with water, just before or with meals.

Avoid skipping meals after taking the dose.

✔️ Drug Interactions

Potentiates Hypoglycemia With:

Insulin, metformin, ACE inhibitors, anabolic steroids, azapropazone, chloramphenicol, ciprofibrate, fluconazole, fluoxetine, coumarins, disopyramide, fenfluramine, MAO inhibitors, miconazole, quinolones, salicylates, sulfonamides, and tetracyclines.

Reduces Hypoglycemic Effect With:

Corticosteroids, diuretics, phenytoin, thyroid hormones, calcium channel blockers, barbiturates, nicotinic acid (high dose), estrogen, rifampicin, and sympathomimetics.

Beta-blockers, clonidine, and reserpine may either enhance or reduce hypoglycemic activity and can mask early symptoms of low blood sugar.

Alcohol intake may unpredictably alter the effect of Glucorid.

✔️ Contraindications

• Type 1 diabetes mellitus
• Diabetic ketoacidosis or diabetic coma
• Severe hepatic or renal impairment
• Dialysis patients
• Known hypersensitivity to Glimepiride, other sulfonylureas, or sulfonamides

✔️ Pregnancy & Lactation

Contraindicated in pregnancy: Switch to insulin for glycemic control.

Breastfeeding: Avoid use — Glimepiride may pass into breast milk and harm the infant.

Discontinue breastfeeding or use alternative therapy as advised by a physician.

✔️ Precautions & Warnings

• Monitor closely during initial weeks of therapy due to increased hypoglycemia risk.
• If hypoglycemia occurs, immediately take glucose or sugar and adjust dosage or meal timing accordingly.
• Dose adjustment is necessary during weight change, illness, or lifestyle alteration.

✔️ Storage:

Store below 30°C, protected from light and moisture.
Keep out of reach of children.